As the series' fourth season came to an end, Jane announced that she was leaving her fiancé and revealed the shocking news that she is pregnant. Meanwhile, the relationship between Maura and Frankie became more complex. As Rizzoli & Isles continues for a fifth exciting season, Jane and Maura will investigate more complex and dangerous cases than ever before, and the team will deal with the loss of a dear friend as they say goodbye to a former colleague, Detective Barry Frost.

Despite being complete opposites, the two women share an offbeat chemistry, an authentic friendship and a unique working relationship that helps them solve Boston's most complex murders. Based on a book series by internationally best-selling crime writer Tess Gerritsen, Rizzoli & Isles also stars Bruce McGill as the seasoned and lovable Detective Vince Korsak; Jordan Bridges as Frankie Rizzoli Jr., Jane's younger brother who now follows in her detective footsteps; and Lorraine Bracco as their nosy but well-meaning mother, Angela Rizzoli, who works at the Boston Police Department café.