A thought-provoking adventure drama that tells the story of Cole (Stanford), a time traveler from the post-apocalyptic future in a high-stakes race against the clock. Utilizing a dangerous and untested method of time travel, he travels from the future to the present day on a mission to locate and eradicate the source of a deadly plague that will eventually decimate the human race. Exploring themes of fate, destiny, love and the possibility of second chances, 12 Monkeys takes place in two separate times: the apocalyptic future (2043) and the present.

In season two Cole and Cassie must travel to different time periods to stop The Army of the 12 Monkeys, whose master plan finally becomes clear.